Search on: ESTROGENIC STEROIDS, ALKYLATED 
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Descriptor English:   Estrogenic Steroids, Alkylated 
Descriptor Spanish:   Esteroides Estrogénicos Alquilados 
Descriptor Portuguese:   Esteróides Estrogênicos Alquilados 
Tree Number:   D06.472.334.851.437.968
Definition English:   Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties. 
Pharmacological Action:   Estrogens
 
History Note English:   2004 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   38106 
Unique Identifier:   D042782 

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